While much is known about the origin and development of celiac disease, there is still much to be discovered. Important issues to be studied include the long-term quality of life of individuals with celiac disease, their psychological welfare, and their ability to adapt to a gluten-free diet. In addition, our laboratory is attempting to discover the mechanisms of the immunological damage in celiac disease. Looking ahead, the Center will continue to pursue pioneering research that explores the relationship of celiac disease to other autoimmune diseases with emphasis on neurological, thyroid, and cardiovascular disorders. We believe in a collaborative approach to research. Most of our studies are conducted in conjunction with experts in other medical disciplines at Columbia University, as well as with other national and international investigators.